đšBreaking: First Hormone-Free Male Birth Control Pill đ. Here is what you need to know. The pill is called YCTâ529, it blocks sperm production without affecting testosterone; 99% effective in animals, reversible, and no major side effects so far. Human trials are moving to
Breakthrough male birth control pill just passed human safety testing
Scientists have been trying to find solutions for decades
It could soon be a woman's world, with a proposed male birth control pill passing the first stage of human trials.
Typically, contraception for men is limited to condoms or the painful process of a vasectomy. Although vasectomies can be reversed, they're largely viewed as a permanent procedure.
There are many more types of contraception for women, but there have been complaints that the responsibility is on them to take the contraceptive pill.
First approved for use in the United States in 1960, the combined oral contraceptive pill (COCP) mixes estrogen with progestin, and when taken correctly, affects the menstrual cycle to prevent pregnancy during sex.
There's been much chatter about science discovering a male version of 'the pill', and according to Scientific American, it's just passed safety tests in its first human trials.
The outlet confirms that YCT-529 is bringing us one step closer to male contraceptive solutions after results from the early phase 1 clinical trial were published in Communications Medicine.


The non-hormonal oral contraceptive temporarily stops sperm production, and when taken daily, YCT-529 blocks a vitamin A metabolite from binding to receptors in the testes.
This stops the chain of gene-expression changes that the body needs to make sperm.
The male contraceptive had been shown to be 99% effective against pregnancies in mice, while it's now the only one on the market currently being tested on humans. Researchers hope to have the pill out by the end of the decade, with trials moving forward.
16 healthy men between the ages of 32 and 59 were selected, with all of them having previously undergone a vasectomy. This specific group was chosen as a precaution in case the trial permanently affected any participants' fertility.
Nadja Mannowetz is the co-founder and chief science officer of YourChoice Therapeutics, who oversaw the trial. While YourChoice Therapeutics didn't look at how efficient the pill was at reducing sperm, it's currently collecting this data in trials.
As pointed out by Stephanie Page, an endocrinologist at the University of Washington School of Medicine, ensuring YCT-529's safety was the first important step.
Page wasn't involved in the study but has worked on male contraceptives for over 20 years and explained: "We really need more reversible contraceptive methods for men."
Mannowetz was happy with the results, noting that the team saw "good and quick bioavailability" across all doses, meaning the pill didn't rapidly break down in the body.
Given that it took between two and three days for the drug availability levels to reduce by half in the blood, it should mean that men would only need to take the pill once a day.
If approved by the U.S. Food and Drug Administration, Mannowetz suspects it will probably be in an 180 mg dose, but follow-up trials hope to find the optimum.
Despite there being no obvious side effects, Page warned: "I think it would be overstating the data to say they know much about side effects yet. Every medication on the market has side effects."
There are several reversible male contraceptives currently in testing, with NES/T being the furthest along. This is applied every day to the shoulders and upper arms as a gel, then absorbed into the bloodstream.
Page concludes that "men are very eager to have more reproductive agency and to participate in contraception," hoping that individuals and couples will get more agency over their sex and reproduction habits.
News in the same category

Why Scallions Deserve More Attention In Your Diet

The Quiet Charm of Homemade Jam

Reaching 60 Without These Conditions

Leg Exercises That Become More Important After 50

Breakfast Habits That Could Be Putting Stress on Your Kidneys

Brittle Nails

Simple Weight Loss Habits

Common Medications That Can Affect Your Balance

Why Your Hands Fall Asleep

Red Swollen Burning Foot

The Benefits of Beetroot

Studies Indicate That Individuals With This Blood Type Have a Higher Likelihood of Living to 100

54-Year-Old Woman Thought Ginger Was Healthy Ate It Daily for 3 Months and Paid a Painful Price

Raise Your Legs Daily

Waking Up With a Dry Mouth at Night

Foods and Drinks That May Slow Weight Loss

Exercises That May Help Relieve Heel Pain Naturally

Drink Cucumber Water Every Morning

Why Do I Fart So Much

Scientists reveal that consumption of TOMATO causes
News Post

PART: 2 The Mark That Returned

đŹ PART 2: «The Father Walked Onto the Stage Before She Could Lie Again»

The Puzzle of Counting Squares That Challenges Everyone (And How to Solve It)

What Would You Do First? The Result Can Reveal a Lot About You

White Passenger Kicked Black Woman Out of First Class â Then She Flashed Her Badge, Silence Fell

He Sacrificed His Life To Help Rescue An Old Woman, Moments Later A Billionaire Pulled Up And This..

âI Can Fix It.âA Homeless Man Heard a Billionaireâs Cry for Help Then He Taught Him What He Couldnât

The Secret Meaning of Black Diamonds on Measuring Tapes

Unlock The Secrets Of Successful Nighttime Adventures With One Brilliant Tool! đŁâš

Only Geniuses Can Solve This Math Puzzle in 10 Seconds: Can You?

If you don't know what it's used for, here's what it means.

Is this going to bite or infest my house?

If you see one of these in your house, BE VERY CAREFULâŠ.

I just found it on my son's head... What is it?

If youâre smart enough to solve this tricky math riddle

Part 2 : He Fed a Hungry BoyâThen This Happened Years Later

Should I be worried about it? And what is it?

Choose One Girl and It Will Reveal What Kind of Child You Were and Who You Truly Are Today

Remember her? She was so pretty. See how she looks now...
