Mesotherapy, a cosmetic procedure that dates back to 1952, is once again gaining popularity after decades of relative obscurity. Originally developed as a medical treatment to relieve pain and improve circulation, mesotherapy has been rebranded in recent years as a quick cosmetic solution for concerns such as under-eye bags, wrinkles, cellulite, and stubborn fat deposits. However, as its popularity surges, many medical professionals are sounding the alarm about its safety, regulation, and long-term effects.

What Is Mesotherapy?

Mesotherapy is a minimally invasive technique that involves injecting a customized mixture of vitamins, enzymes, hormones, plant extracts, and other active substances directly into the middle layer of the skin, known as the mesoderm. The intended purpose is to rejuvenate the skin, improve elasticity, and break down localized fat cells.

Although the procedure does not involve surgery, it is far from risk-free. Immediately after treatment, patients often experience raised bumps across the skin, creating a honeycomb- or reptile-like appearance that can last for hours or even days. Swelling, redness, and tenderness at the injection sites are also common.

A Social Media–Driven Comeback

Platforms such as TikTok and Instagram have played a major role in mesotherapy’s resurgence. Influencers frequently post videos showing dramatic “before-and-after” results, often claiming visible improvements in minutes. This viral exposure has fueled demand, particularly among younger audiences seeking fast and affordable cosmetic enhancements.

Adding to the concern, DIY mesotherapy kits are now widely available online for as little as $45, making the procedure accessible to individuals with no medical training. Experts strongly advise against self-administered injections, warning that improper technique and unknown substances can significantly increase the risk of serious complications.

Lack of Regulation and Standardization

Unlike FDA-approved cosmetic treatments, mesotherapy formulas are not standardized or strictly regulated. Each provider may use a different cocktail of ingredients, sometimes including prescription medications, compounded substances, or products that lack clinical testing. This variability makes it difficult to predict outcomes and increases the likelihood of adverse reactions.

Dr. Viktoryia Kazlouskaya, a dermatologist based in New York, cautions that mesotherapy can result in severe and lasting damage—especially when performed by untrained individuals or outside a medical setting. Reported complications include prolonged bruising, infections, allergic reactions, skin necrosis, scarring, and even permanent eye damage when injections are done near the orbital area.

Proceeding With Caution

While the promise of quick, non-surgical cosmetic fixes can be tempting, experts emphasize that mesotherapy should not be viewed as a harmless beauty trend. The lack of regulation, combined with the growing availability of at-home kits, presents serious safety concerns.

Anyone considering mesotherapy should consult a qualified medical professional, ask detailed questions about the substances being injected, and fully understand the potential risks involved. In many cases, safer, FDA-approved alternatives may provide similar benefits with fewer uncertainties.

In cosmetic medicine, informed decision-making is just as important as the results themselves. Prioritizing safety over trends can help protect both appearance and long-term health.